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Target intelligence / Profile preview
Mannose-Binding Lectin 2 (MBL2)
- Target
- MBL2
- Molecular classification
- C-type lectin, Collectin
01
Overview
Mannose-binding lectin (MBL), encoded by the MBL2 gene, is a key component of the innate immune system. It functions as a pattern recognition receptor, binding to specific carbohydrate structures on pathogens and initiating the lectin pathway of complement activation. This leads to opsonization, phagocytosis, and inflammation, ultimately contributing to pathogen clearance. Deficiency in MBL increases susceptibility to infections, particularly in early childhood.
- Other names
- Mannose-binding lectinMBPMannan-binding protein
02
Biological functions
Pattern recognitionComplement activation (lectin pathway)OpsonizationModulation of cytokine productionPhagocytosis enhancement
03
Disease associations
InfectionImmune deficiency
04
Safety considerations
Increased susceptibility to infections in MBL-deficient individuals
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