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Target intelligence / Profile preview
Mannose-Binding Lectin Complement Pathway (MBL Pathway)
- Target
- MBL Pathway
- Molecular classification
- Complement Pathway, Innate Immunity Pathway, Pattern Recognition Receptor Pathway
01
Overview
The mannose-binding lectin (MBL) complement pathway, also known as the lectin pathway, is one of the three main pathways that activate the complement system—a crucial part of innate immunity. This pathway is initiated by pattern recognition molecules such as MBL, ficolins, and collectin-11 (CL-K1), which bind to specific carbohydrate patterns on microbial surfaces or altered self-cells. Upon ligand binding these molecules recruit serine proteases that trigger a proteolytic cascade resulting in robust antimicrobial activity.
- Other names
- Mannan-binding lectin/protein pathwayLectin complement activation pathway
02
Biological functions
Complement activationOpsonizationPhagocytosisCell lysisInflammationImmune responseApoptosis clearance
03
Disease associations
InfectionInflammatory diseasesMyocardial reperfusion injuryAutoimmune diseases
04
Safety considerations
Increased risk of infection in deficient individualsPotential for excessive inflammationDysregulation in autoimmune diseases
05
Biomarkers
MBL levelsMASP activity
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