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Lectin Pathway (LP)
- Target
- LP
- Molecular classification
- Enzyme cascade, Pattern Recognition Receptor (PRR) pathway, Complement pathway
01
Overview
The lectin pathway is a critical component of the innate immune system, initiating complement activation through the recognition of carbohydrate patterns on pathogens or altered self-cells by pattern recognition molecules like MBL, ficolins, and collectins. This leads to the activation of MASPs, cleavage of C4 and C2, and formation of the C3 convertase, ultimately resulting in opsonization, cell lysis, and inflammation. Dysregulation of the lectin pathway is implicated in various diseases, including infections, autoimmune conditions, and thrombotic events.
- Other names
- Mannose-binding lectin pathwayMBL pathwayFicolin pathwayCollectin pathway
02
Mechanism of action
N/A
03
Biological functions
Innate immunityOpsonizationComplement activationCell lysisInflammationAdaptive immune response guidancePathogen recognitionApoptosis/necrosis clearance
04
Disease associations
Infectious diseasesAutoimmune diseasesInflammatory disordersThrombotic complicationsStrokeKidney diseasesCOVID-19 pathologyCancer (tumor suppression)
05
Safety considerations
Uncontrolled complement activation can lead to inflammatory damageComplement deficiencies increase infection susceptibilityPotential for off-target effects when modulating complement componentsThrombotic complications
06
Biomarkers
MBL levelsFicolin levelsMASP-2 levelsC4bC3aC5a
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