Mannose-containing glycoprotein on extracellular vesicle

Mannose-containing glycoproteins on extracellular vesicles refer to a class of proteins present on the surface of EVs—such as exosomes, microvesicles, and apoptotic bodies—that are post-translationally modified with mannose-rich glycans. These modifications are part of the broader process known as glycosylation. The presence and patterning of these mannose residues can influence several biological processes: > "Specific modification of the glycocalyx allowed high levels of mannose to be expressed on extracellular vesicles generated after apoptosis." [1] Glycosylation—including mannosylation—affects how EVs interact with recipient cells, their uptake mechanisms, their stability in circulation, and their ability to modulate immune responses or promote metastasis within the tumor microenvironment[1][5]. The heterogeneity in structure and function among different classes and sources of EVs is partly due to differences in surface glycans such as mannose-containing moieties[2]. These molecules are not considered classical therapeutic targets like receptors or enzymes; rather, they represent structural features that may serve as biomarkers for disease states such as cancer or infection due to their altered expression patterns under pathological conditions[2][6]. There is currently no evidence that drugs directly target these specific structures. Because "mannose-containing glycoproteins on extracellular vesicles" describes a broad molecular feature rather than a single defined molecule or receptor—and does not correspond to an established therapeutic target—the entry is marked as incorrect for structured drug-target databases.

Other names

Mannosylated glycoprotein on extracellular vesicleGlycosylated protein with mannose residues on EVMannose-rich glycoprotein on exosome