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Target intelligence / Profile preview
Mannose Receptor C-type 1 (MRC1)
- Target
- MRC1
- Molecular classification
- C-type lectin family, Receptor, Transmembrane protein
01
Overview
Mannose Receptor C-type 1 (MRC1), also known as CD206, is a type I transmembrane protein belonging to the C-type lectin family. It functions as an endocytic and phagocytic receptor, recognizing high-mannose glycans on pathogens and endogenous proteins. MRC1 plays a crucial role in innate immunity, immune modulation, and antigen presentation. Dysregulation of MRC1 is implicated in infectious diseases, inflammatory disorders, and cancer, making it a potential therapeutic target and biomarker.
- Other names
- CD206Mannose receptor
02
Biological functions
EndocytosisPhagocytosisPathogen recognitionImmune modulationAntigen presentation
03
Disease associations
Infectious diseasesInflammatory disordersCancer
04
Biomarkers
Serum soluble mannose receptor (disease activity/severity)
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