Mannose receptor C-type 1 (MRC1) (MRC1)

Mannose receptor C-type 1 (MRC1), also known as CD206, is a 175 kDa transmembrane glycoprotein primarily expressed on the surface of macrophages and dendritic cells. It belongs to the C-type lectin superfamily and plays a pivotal role in the innate immune system by recognizing and internalizing glycoconjugates with terminal mannose, fucose, or N-acetylglucosamine residues. This function allows MRC1 to act as a pattern recognition receptor (PRR) for various pathogens, including bacteria, fungi, and viruses, facilitating their phagocytosis and subsequent lysosomal degradation. Beyond its role in host defense, MRC1 is a well-established marker for M2-polarized macrophages, which are involved in tissue repair and tumor progression. Therapeutically, MRC1 is targeted by ligands like D-mannose and diagnostic agents such as Technetium Tc 99m tilmanocept, which is used for lymphatic mapping in cancer patients. While D-mannose is also widely known for its use in treating urinary tract infections by binding to the bacterial FimH adhesin, MRC1 remains its primary human receptor involved in immune modulation and pathogen clearance.

Other names

CD206Macrophage mannose receptor 1MMRCLEC13D

Binding to terminal mannose, fucose, or N-acetylglucosamine residues on glycoproteins or pathogens, facilitating endocytosis and lysosomal degradation.