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Mannosidase alpha class 1B member 1 pseudogene

Molecular classification: Other (pseudogene)

Overview

Mannosidase alpha class 1B member 1 pseudogene is a non-functional genomic locus with sequence similarity to MAN1B1, but it does not encode an active enzyme. The functional gene MAN1B1 (Ensembl: ENSG00000177239) encodes an alpha-mannosidase involved in N-glycan processing and endoplasmic reticulum-associated degradation (ERAD). Mutations in the protein-coding MAN1B1 gene cause congenital disorders of glycosylation, but pseudogenes like ENSG00000271028 are not themselves implicated in disease or therapeutic intervention[1][2][3][4].

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