Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
MAP kinase-activated protein kinase 3 (MAPKAPK3)
- Target
- MAPKAPK3
- Molecular classification
- Enzyme, Serine/threonine-protein kinase, Kinase
01
Overview
MAP kinase-activated protein kinase 3 (MAPKAPK3) is a serine/threonine protein kinase activated downstream of mitogen-activated protein kinases (MAPKs) such as p38, ERK, and JNK. As a member of the MAPKAPK subfamily, it acts as an integrative node for mitogenic and stress signals, regulating cellular processes that include gene expression, cytokine production, endocytosis, cell migration, chromatin remodeling, and transcriptional regulation. MAPKAPK3 is implicated in various pathophysiological conditions such as cancer (notably glioma), inflammation, metabolic, and infectious diseases. Its enzymatic activity consists of phosphorylating serine residues on targets, modulating diverse signaling networks that control cell fate and immune responses
- Other names
- MAPKAP kinase 3MK33pKChromosome 3p kinaseMAPK-activated protein kinase 3EC 2.7.11.1
02
Mechanism of action
Inhibition of kinase activity through ATP-competitive binding or allosteric inhibition (inferred from kinase class; specific drug MoA not stated in provided results)
03
Biological functions
Signal transductionRegulation of gene expressionCytokine productionEndocytosisCell migrationChromatin remodelingTranscriptional regulationCell differentiationStress response
04
Disease associations
CancerGliomaInflammationGlomerulonephritisSkin diseaseInfection (e.g., influenza A virus)DiabetesMacular dystrophyMalaria
05
Safety considerations
No specific safety concerns provided; general kinase inhibitor challenges such as off-target effects and pathway redundancy are likely relevant (based on molecular class)
06
Biomarkers
Overexpression in glioma suggests utility as a prognostic or disease progression marker in glioma
Beyond the preview
Go deeper on MAP kinase-activated protein kinase 3 (MAPKAPK3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on MAP kinase-activated protein kinase 3 (MAPKAPK3).