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Target intelligence / Profile preview
MAP kinase-interacting serine/threonine-protein kinase 2 (MNK2)
- Target
- MNK2
- Molecular classification
- Enzyme, Serine/threonine-protein kinase
01
Overview
MAP kinase-interacting serine/threonine-protein kinase 2 (MNK2) is a serine/threonine kinase that phosphorylates eukaryotic translation initiation factor 4E (EIF4E), regulating translation initiation in response to environmental stress and cytokines. It is activated by MAP kinases, such as ERK and p38, and plays roles in cell growth regulation, oncogenesis, and chemoresistance. MNK2 is considered a therapeutic target in cancer and diabetes.
- Other names
- GPRK7MAP kinase interacting serine/threonine kinase 2MAPK interacting serine/threonine kinase 2MAP kinase signal-integrating kinase 2
02
Mechanism of action
Inhibition of MNK2 kinase activity; disruption of MNK2-eIF4G interaction
03
Biological functions
Signal transductionCell growth regulationRegulation of translationApoptosis regulationRegulation of hematopoiesisAdipocyte metabolism regulationMacrophage polarization
04
Disease associations
CancerDiabetesAutoimmune diseasesInflammation
05
Safety considerations
Potential for off-target effects due to kinase family similarityComplex role in multiple cellular processes requiring careful consideration of context-dependent effects
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