MAP3K7 C-terminal-like protein (MAP3K7CL)

MAP3K7 C-terminal-like protein (MAP3K7CL) is a protein encoded by the MAP3K7CL gene on human chromosome 21. Despite its name, which implies a relationship to MAP3K7 (TAK1), the function of MAP3K7CL remains unclear, and there is little evidence it acts as a kinase or participates in well-characterized signaling pathways. It is a protein-coding gene expressed in peripheral blood leukocytes and other tissues and is listed as being associated with certain cancers (like skin sarcoma) in some gene databases, but there is no established evidence for it serving as a therapeutic target, biomarker, or having any defined molecular function or disease mechanism at this time[3][4][5][6]. Notes on ambiguity: - MAP3K7CL is not the same as MAP3K7/TAK1, which *is* a known kinase with well-characterized functions; do not confuse the two[1][2]. - Some aliases (e.g., TAK1L, TAKL) might cause confusion with MAP3K7 (TAK1), but these are distinct genes and proteins. - No evidence supports MAP3K7CL as a receptor, enzyme, or therapeutic target; no drugs or clinical guidelines reference it as such. If structured data is required, most fields—especially those relating to pharmacology or clinical relevance—should remain null due to the current lack of characterization.

Other names

MAP3K7CLC21orf7TAK1LTAKLTAKL-1TAKL-2TAKL-4MAP3K7 C-terminal-like proteinTAK1-like proteinHC21ORF7TAK1-like protein 1TAK1-like protein 2TAK1-like protein 4TGF-beta activated kinase