MAP4K3 divergent transcript (MAP4K3-DT)

MAP4K3 divergent transcript (MAP4K3-DT) is a long non-coding RNA (lncRNA) gene located close to the protein-coding MAP4K3 gene, but does not code for a protein. As a lncRNA, it may play regulatory roles in gene expression, though its specific biological function, disease involvement, or pharmacological relevance is currently unknown. It is classified as a divergent transcript, meaning it is situated within a few hundred nucleotides of a protein-coding gene, typically transcribed in the opposite direction[3][5][7]. Key distinction: MAP4K3-DT is different from MAP4K3, which is a protein-coding gene also called GLK and is involved in cellular signaling, immune regulation, and has been studied as a potential therapeutic target in autoimmune diseases and cancer[1][4][8]. MAP4K3-DT, however, is a non-coding RNA and not a protein target. No evidence supports MAP4K3-DT as a receptor, enzyme, transporter, or other classical drug target[3][5][7].

Other names

MAP4K3-DTMAP4K3 divergent transcriptENSG00000231312NCBI 728730HGNC:54056[3]

Not applicable; there are no drugs targeting this lncRNA[3][7]