MAP7 domain-containing protein 2 (MAP7D2)

MAP7 domain-containing protein 2 (MAP7D2) is a member of the MAP7 family of microtubule-associated proteins that plays a critical role in stabilizing microtubules and regulating microtubule dynamics within cells[2][3]. It binds directly to microtubules via its positively charged N-terminal region and enhances microtubule polymerization and bundling, especially in neuronal and testicular tissues[2]. MAP7D2 also interacts with kinesin-1 (Kif5b), facilitating the tethering of this motor protein to microtubules and promoting axonal transport functions[2][3]. Loss of MAP7D2 disrupts microtubule stability, alters cell motility, and increases neurite outgrowth, indicating its involvement in neuronal development. While primarily studied for its structural cell biology roles, dysregulation of MAP7 family proteins such as MAP7D2 has been linked to neurodegeneration, including roles described in Parkinson’s disease models[3]. There are currently no known therapeutic agents directly targeting MAP7D2.

Other names

MAP7D2FLJ14503MAP7 domain containing 2 brainMAP7 domain containing protein variant 1MAP7 domain containing protein variant 2