MAP7 domain-containing protein 3 (MAP7D3)

MAP7 domain-containing protein 3 (MAP7D3) is a member of the microtubule-associated protein 7 (MAP7) family and functions to promote microtubule assembly and stability by binding to microtubules via conserved coiled-coil and MAP7 domains, especially at the mitotic spindle[1]. MAP7D3 is involved in the organization of the microtubule cytoskeleton, mitotic spindle formation, and cellular processes such as migration, polarization, and differentiation[1][4]. Elevated expression of MAP7D3 is associated with increased invasiveness and metastatic potential in triple-negative breast cancer, where it acts as a prognostic marker and modulates cell proliferation, migration, drug resistance, and cancer-initiating properties[2]. MAP7D3 is not considered a classical therapeutic target or receptor, and there are no drugs that directly bind to it, but its depletion increases sensitivity to microtubule-active chemotherapeutics such as docetaxel and nucleoside analogs such as gemcitabine in cancer models[2].

Other names

MAP7D3MDP3FLJ12649MAP7 domain containing 3MAP7 domain-containing protein 3

Microtubule stabilization and assembly; knockdown increases sensitivity to microtubule-targeting agents (docetaxel) and nucleoside analogs (gemcitabine)