MAPKAPK5 antisense RNA 1 (MAPKAPK5-AS1)

MAPKAPK5 antisense RNA 1 (MAPKAPK5-AS1) is a long noncoding RNA (lncRNA) transcribed from the antisense strand of the MAPKAPK5 (MK5) gene locus on chromosome 12. It functions primarily as a regulatory RNA and does not encode a protein. MAPKAPK5-AS1 plays oncogenic roles in multiple cancers, including colorectal cancer, hepatocellular carcinoma, and lung adenocarcinoma, where it is often upregulated. Mechanistically, it modulates gene expression through several pathways: - It acts as a competing endogenous RNA (ceRNA) by sponging microRNAs such as let-7f-1-3p and miR-376b-5p to regulate downstream targets including SNAI1 and ECT2[1][3][7]. - It regulates the nearby protein-coding MAPKAPK5 gene in cis, influencing processes like c-Jun phosphorylation and cell cycle progression[1][2][4][5]. - It interacts with proteins (e.g., EZH2, RBM4, eIF4A1) to influence cell proliferation, apoptosis, migration, invasion, and remodel the tumor microenvironment[1][2][3][5]. MAPKAPK5-AS1 overexpression is associated with tumor progression, metastasis (especially liver in colon cancer), immune microenvironment changes, and poor clinical prognosis, identifying it as a promising oncogenic biomarker but not a classical druggable target, since it is a lncRNA and not a traditional receptor, enzyme, or protein-coding gene[1][2][3][4][5][7].

Other names

C12orf47FLJ39616MAASlncRNA-cCSC1MAPKAPK5 antisense gene protein 1apoptosis-related protein PNAS-1

Not applicable; MAPKAPK5-AS1 functions primarily via noncoding RNA mechanisms such as acting as a competing endogenous RNA (ceRNA) and recruitment of regulatory proteins (e.g., binding EZH2, modulating miRNAs, or recruiting RBM4/eIF4A1) to regulate adjacent protein-coding genes and cellular pathways[1][2][3][4][5][7].