Marburg marburgvirus Glycoprotein (None)

The Marburg marburgvirus glycoprotein (GP) is the sole surface protein of the virus and plays a central role in viral attachment, entry, and fusion with host cells. It is a type I transmembrane protein that forms homotrimeric spikes on the viral envelope. The GP gene is encoded by the fourth gene in the Marburg virus genome. It mediates recognition of cellular receptors—primarily Niemann-Pick C1 (NPC1)—and facilitates entry into target cells through endocytosis followed by membrane fusion. As it is exposed on virion surfaces during infection, it serves as a major target for neutralizing antibodies.

Blocking attachment/fusion steps to prevent viral entry