Marburg virus VP24 protein (VP24)

Marburg virus VP24 protein is a minor matrix protein integral to the viral life cycle. It is involved in the assembly of the viral nucleocapsid and in budding of new virus particles from the host cell. VP24 colocalizes with nucleoprotein inclusions in infected cells and displays membrane-binding properties but cannot form virus-like particles (VLPs) independently—it is incorporated into VLPs by association with the major matrix protein VP40. Inhibition or silencing of VP24 reduces release of Marburg virions. Structurally, Marburg VP24 has a single-domain alpha/beta fold with a unique projecting β-shelf, distinct from ebolavirus VP24, and does not possess the strong immunosuppressive function of its Ebola counterpart[1][3][4][8].

Other names

MARV VP24minor matrix protein VP24mVP24

Experimental antivirals could act by inhibiting VP24’s interaction with other viral proteins or with membranes, thereby impairing virion assembly and release