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Target intelligence / Profile preview
MAS proto-oncogene receptor (MASR)
- Target
- MASR
- Molecular classification
- G protein-coupled receptor
01
Overview
The MAS proto-oncogene receptor (MASR), also known as MAS1, is a G protein-coupled receptor (GPCR) activated by angiotensin-(1–7). It is involved in vasodilation, anti-proliferative actions, anti-inflammatory responses, cardioprotection, and regulation of glucose homeostasis. The ACE2-Ang-(1–7)-MAS axis plays an important role in cardiovascular health and disease modulation such as myocardial remodeling and cancer progression. MASR acts as a functional antagonist to AGTR1.
- Other names
- MAS1MGRAMRGAMas
02
Mechanism of action
Activation of Gq proteins, phospholipase C signaling pathway activation, downstream activation of ERK/MAPK, PI3K/AKT/mTOR, RHO family GTPases, suppression of NFκB signaling, modulation of vascular endothelial growth factor signaling.
03
Biological functions
Signal transductionVasodilationAnti-inflammationAnti-proliferationCardioprotectionRegulation of glucose homeostasis
04
Disease associations
CancerCardiovascular diseaseRare metabolic syndromes
05
Interacting drugs
Angiotensin-(1–7)
2 more in the full profile.
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