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Target intelligence / Profile preview
MAS Receptor (MAS1)
- Target
- MAS1
- Molecular classification
- G protein-coupled receptor
01
Overview
The MAS receptor (MAS1) is a G protein-coupled receptor and a key component of the renin-angiotensin system (RAS). It is primarily activated by angiotensin-(1–7), leading to vasodilation, anti-inflammatory, anti-fibrotic, and anti-thrombotic effects. The MAS receptor acts as a counter-regulatory component within the RAS, opposing the actions of angiotensin II. Its broad tissue distribution suggests additional functions beyond blood pressure control, potentially including roles in behavior or metabolism.
- Other names
- MAS1 oncogeneMAS proto-oncogeneMRGAMGRAMAS
02
Mechanism of action
Agonists activate the MAS receptor, leading to downstream signaling via Gαq, Gαi/s, and Gα12 proteins. This results in increased intracellular calcium, modulation of cAMP levels, and cytoskeletal rearrangement.
03
Biological functions
VasodilationAnti-inflammatory effectsAnti-fibrotic effectsAnti-thrombotic effectsBlood pressure regulationFluid balanceOxidative stress modulationClotting controlSignal transduction
04
Disease associations
Cardiovascular diseaseRenal diseaseMetabolic disordersBehavioral disorders
05
Safety considerations
Knockout studies show both detrimental and beneficial outcomes depending on context, suggesting complex involvement across multiple organ systems.Potential for off-target effects due to structural similarity with other GPCRs, particularly within the Mrgpr family.
06
Interacting drugs
Angiotensin-(1–7)
2 more in the full profile.
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