Mas receptor–endothelin type B receptor complex (MasR:ETBR)

The Mas receptor–endothelin type B receptor complex is a functional heteromer formed by the association of the Mas receptor (MasR) and the endothelin type B receptor (ETBR) [1, 2]. This complex serves as a vital regulatory unit in the vascular endothelium, where it facilitates crosstalk between the renin-angiotensin system and the endothelin system [1]. Specifically, the interaction amplifies the signaling of angiotensin-(1-7) and promotes the vasoprotective actions of endothelin-1 through the ETBR, such as the activation of endothelial nitric oxide synthase (eNOS) and the production of nitric oxide (NO) [1, 2]. This synergy is essential for maintaining vascular homeostasis, inducing vasodilation, and preventing inflammation and vascular remodeling [1]. Dysregulation or dissociation of the MasR:ETBR complex is associated with cardiovascular pathologies, including pulmonary hypertension and endothelial dysfunction [1, 2]. Consequently, the complex is an emerging therapeutic target, with research focusing on "enhancers" that stabilize the heteromer to restore or boost its protective signaling in diseased states [1]. Pharmacological modulation of this complex offers a more nuanced approach than simple receptor antagonism, potentially avoiding the side effects associated with blocking individual receptors [1, 3].

Other names

Mas-ETB heteromerMas-ETB receptor complexMAS1-EDNRB complexMasR:ETBR interaction

Enhancement of receptor heteromerization to amplify vasoprotective signaling pathways, specifically eNOS activation and nitric oxide production.