Mas-related G protein-coupled receptor C11 (MrgprC11)

Mas-related G protein-coupled receptor C11 (MrgprC11) is a member of the Mas-related GPCR subfamily, a group of class A (rhodopsin-like) G protein-coupled receptors primarily found in small-diameter, sensory neurons of the dorsal root ganglia in rodents. MrgprC11 is involved in the detection and modulation of noxious stimuli, including pain and itch, and has become a focus of research as a potential novel target for the treatment of persistent pain syndromes and chronic itch. In experimental models, activation of MrgprC11 with the peptide agonist BAM8-22 yields analgesic and antipruritic effects, suggesting therapeutic promise. MrgprC11 couples primarily to Gi and Gq signaling pathways, leading to the inhibition of neuronal excitability. Its expression pattern is highly restricted to sensory neurons, which may offer the opportunity for selective therapeutic modulation with minimal systemic side effects. Current evidence for MrgprC11 comes largely from rodent studies; no pathophysiologically equivalent receptor ortholog is established in humans, but related MRGPRX receptors exist.

Other names

MrgprC11Mrgprc11 (mouse)MAS-related GPRCBAM22 receptor

Agonists (such as BAM8-22) activate MrgprC11 in nociceptive neurons, leading to inhibition of high voltage–activated calcium channels and reduced neurotransmitter release, thereby modulating pain transmission. Engages downstream Gi and Gq protein signaling pathways