Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Mast Cell (None)
- Target
- None
- Molecular classification
- Immune cell, Granulocyte, Tissue-resident cell
01
Overview
Mast cells are tissue-resident immune cells crucial in allergic reactions, inflammation, and host defense. They release mediators like histamine, heparin, and cytokines upon activation via various mechanisms, including IgE cross-linking, DAMP/PAMP recognition, and complement activation. Dysregulation leads to diseases like asthma, mastocytosis, and MCAS.
02
Mechanism of action
Drugs targeting mast cells aim to inhibit their activation, mediator release, or downstream effects. Antihistamines block histamine receptors, mast cell stabilizers prevent degranulation, epinephrine reverses anaphylaxis, anti-IgE antibodies reduce IgE levels, and corticosteroids suppress inflammation.
03
Biological functions
Allergic responseInflammationHost defenseImmune regulationAngiogenesisTissue repair
04
Disease associations
Allergic diseases (asthma/allergic rhinitis/anaphylaxis)MastocytosisMast Cell Activation Syndrome (MCAS)Hereditary Alpha Tryptasemia
05
Safety considerations
Potential for systemic side effects with mast cell stabilizers and corticosteroids.Epinephrine can cause cardiovascular side effects.Anaphylactic reactions to medications used to treat mast cell disorders.Unpredictable mast cell activation in MCAS.
06
Interacting drugs
Antihistamines
4 more in the full profile.
07
Biomarkers
Serum tryptaseHistamine levelsProstaglandin D2 (PGD2) levelsLeukotriene levelsN-methylhistamine
Beyond the preview
Go deeper on Mast Cell (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Mast Cell (None).