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Target intelligence / Profile preview
Mast Cell Calcium Channels (N/A)
- Target
- N/A
- Molecular classification
- Ion Channel, Calcium Channel, CRAC Channel, Orai Channel, TRP Channel
01
Overview
Mast cell calcium channels, primarily CRAC channels composed of Orai1 subunits and regulated by STIM1, are essential for calcium influx and subsequent mast cell activation. This process is crucial for degranulation, cytokine production, and other inflammatory responses. Targeting these channels offers therapeutic potential for allergic and inflammatory diseases.
- Other names
- Mast Cell Calcium Influx PathwaysMast Cell SOCE ChannelsMast Cell CRAC Channels
02
Mechanism of action
Inhibition of calcium influx; modulation of store-operated calcium entry
03
Biological functions
Calcium SignalingCell ActivationDegranulationCytokine ProductionEicosanoid GenerationChemotaxisImmune Response
04
Disease associations
AllergyInflammationAsthmaAtopic DermatitisMastocytosis
05
Safety considerations
Potential for immunosuppressionOff-target effects on other calcium channelsDisruption of calcium homeostasis
06
Interacting drugs
Orai1 inhibitors
2 more in the full profile.
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