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Target intelligence / Profile preview
Mast Cell Histamine Release (MCHR)
- Target
- MCHR
- Molecular classification
- Cellular process, Immune response
01
Overview
Mast cell histamine release is the process by which mast cells release histamine, a potent mediator of inflammation, in response to various stimuli. This release is a central event in allergic reactions and other immune responses, leading to vasodilation, increased vascular permeability, and other inflammatory effects.
- Other names
- Mast cell degranulationHistamine secretion from mast cells
02
Mechanism of action
Calcium-dependent exocytosis of histamine-containing granules in response to various stimuli, including IgE crosslinking, complement activation, and direct chemical stimulation.
03
Biological functions
InflammationImmune responseVasodilationIncreased vascular permeability
04
Disease associations
Allergic diseasesUrticariaAnaphylaxisAsthmaRhinitisConjunctivitisMast Cell Activation Syndrome (MCAS)
05
Safety considerations
Systemic vasodilationHypotensionBronchoconstrictionIncreased vascular permeability leading to edema
06
Interacting drugs
Morphine
3 more in the full profile.
07
Biomarkers
Serum tryptaseUrinary N-methylhistaminePlasma histamine
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