Mast cell immunoglobulin-like receptor 1 (MILR1)

Mast cell immunoglobulin-like receptor 1 (MILR1), also known as Allergin-1, is a transmembrane inhibitory receptor primarily expressed on mast cells[1][2][6]. This receptor belongs to the immunoglobulin superfamily and operates by negatively regulating IgE-mediated mast cell activation, thereby suppressing degranulation and limiting type I immediate hypersensitivity responses (allergic reactions)[1][2]. MILR1 is localized at the plasma membrane where it functions as a cell surface signaling receptor[1][2]. It has potential relevance in allergic diseases, mitochondrial disorders, and variable expression across cancer tissues, although its role as a direct therapeutic drug target remains under investigation[1][4][6].

Other names

Allergin-1C17orf60MCA-32MCA32allergy inhibitory receptor 1mast cell antigen 32probable mast cell antigen 32 homolog

Drugs would act by modulating receptor function to regulate mast cell activation (hypothetical, specific clinical drugs not listed in current sources)