Mastermind-like protein 1 (MAML1)

Mastermind-like protein 1 (MAML1) is a nuclear transcriptional coactivator that acts as a central integrator of the Notch signaling cascade by forming a ternary complex with the Notch intracellular domain and CSL DNA-binding protein, thereby activating target gene expression. MAML1 also modulates other major pathways, particularly Wnt/β-catenin-mediated transcription, and interacts with pivotal transcription factors such as MEF2C and p53, coordinating cellular processes including differentiation, proliferation, and apoptosis. Alterations in MAML1 activity are implicated in the development of diverse malignancies and muscle diseases, positioning it as a key node in transcriptional regulation and a potential point of therapeutic intervention.

Other names

Mastermind-like transcriptional coactivator 1KIAA0200Mam-1mastermind homologMam1mastermind-like 1MAML1

Indirect inhibition via Notch pathway antagonists (such as γ-secretase inhibitors, which prevent the formation of the active Notch intracellular domain needed for MAML1 complex formation). Dominant-negative MAML1 constructs used experimentally block coactivation functions.