Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Maternal Embryonic Leucine Zipper Kinase (MELK)
- Target
- MELK
- Molecular classification
- Serine/threonine protein kinase, Enzyme, AMPK/Snf1 protein kinases
01
Overview
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine protein kinase involved in cell cycle regulation, stem cell self-renewal, apoptosis, splicing regulation, and gene expression. It plays a role in embryonic development, hematopoiesis, and oncogenesis, with high expression observed in various cancers. Pharmacological inhibition of MELK has shown preclinical efficacy in impairing tumor growth, but recent studies suggest its necessity may be context-dependent. Clinical trials are ongoing for inhibitors targeting MELK.
02
Mechanism of action
Inhibition of MELK kinase activity, leading to G2/M arrest and apoptosis in cancer cells.
03
Biological functions
Cell cycle controlApoptosisSplicing regulationStem cell self-renewalEmbryonic developmentHematopoiesisRegulation of gene expression
04
Disease associations
Cancer
05
Safety considerations
Context-dependent efficacyPotential for off-target effectsResistance mechanisms
06
Interacting drugs
OTSSP167
07
Biomarkers
MELK expression levels in tumor tissue
Beyond the preview
Go deeper on Maternal Embryonic Leucine Zipper Kinase (MELK).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Maternal Embryonic Leucine Zipper Kinase (MELK).