Maternally expressed gene 9 (non-protein coding) (MEG9)

Maternally expressed gene 9 (MEG9) is a non-protein coding RNA classified as a long intergenic non-coding RNA (lincRNA), located in the DLK1-DIO3 imprinted cluster on chromosome 14. MEG9 is a maternally imprinted gene, meaning only the maternal allele is expressed. It is involved in diverse regulatory functions, particularly in fine-tuning gene expression and chromatin architecture through epigenetic mechanisms. MEG9 has been found to be robustly induced in response to DNA damage and is believed to play a role in protecting vascular integrity. Aberrations in the expression or imprinting of MEG9 are associated with several diseases, including cancer and imprinting syndromes such as Kagami-Ogata syndrome. Unlike proteins, MEG9 functions at the RNA level through various regulatory interactions and does not have enzymatic or receptor activity. Currently, MEG9 is not established as a direct therapeutic target, and no drugs are reported to interact directly with this RNA[1][3][5].

Other names

LINC00584long intergenic non-protein coding RNA 584C14orf89NCRNA00225MIR381 host gene (non-protein coding)MIR381HGMeg9/MirgMEG9 RNA gene