Matrilin-2 (MATN2)

Matrilin-2 (MATN2) is the largest member of the matrilin family of extracellular matrix adaptor proteins, characterized by a modular structure including von Willebrand factor A (vWFA) domains, multiple epidermal growth factor (EGF)-like repeats, and a coiled-coil oligomerization domain[1][2][4]. It forms homo- and heterooligomers, binding and linking various collagenous and non-collagenous matrix proteins (e.g., collagens, fibronectin, fibrillin-2, laminin-nidogen) to organize and stabilize filamentous extracellular networks[1][3]. MATN2 is broadly expressed in connective tissues, basement membranes, skin, muscle, nerves, and several organs, supporting homeostasis and tissue architecture[2][4]. Functionally, it promotes cell adhesion, neurite outgrowth, Schwann cell migration, neuromuscular junction formation, tissue repair, and influences processes like muscle regeneration and skin wound healing[2][4]. Loss of MATN2 leads to markedly delayed tissue repair and impaired axonal regeneration, although knockout mice are viable under laboratory conditions[2][4]. MATN2's expression and function have been associated with tumorigenesis, nerve and liver regeneration, and specific roles in disease contexts such as liver cirrhosis, hepatocellular carcinoma, and certain brain tumors[2][1]. Alternative splicing generates different protein variants with tissue-dependent functions and regulation[1]. No approved drugs are known to directly target MATN2, and it is not currently considered a direct therapeutic target, although its regulatory roles in tissue remodeling and disease contexts suggest research interest in its pathways[2][3][1].

Other names

Matrilin-2MATN2UNQ193/PRO219testis tissue sperm-binding protein Li 94mP