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Matriptase (None)
- Target
- None
- Molecular classification
- Enzyme, Serine Protease, Type II transmembrane protein
01
Overview
Matriptase, also known as ST14, is a type II transmembrane serine protease that plays essential roles in physiological processes and disease. It is widely expressed in most human epithelial tissues and functions as an epithelial membrane activator for other proteases and growth factors. Key roles include skin barrier formation, epidermal differentiation, and regulation of intestinal epithelial barrier integrity. Dysregulation of matriptase has been implicated in cancer, genetic disorders, and inflammatory diseases, making it a potential target for anti-cancer therapy.
- Other names
- ST14ARCI11HAIMT-SP1MTSP1PRSS14SNC19TADG15TADG-15TMPRSS14Epithin
02
Mechanism of action
Serine protease inhibition
03
Biological functions
ProteolysisActivation of proteasesActivation of growth factorsEpidermal differentiationSkin barrier formationRegulation of intestinal epithelial barrier
04
Disease associations
CancerGenetic DisordersInflammatory Diseases
05
Safety considerations
Potential for off-target effects due to broad expression in epithelial tissuesComplex regulation and potential for paradoxical effects (tumor promotion vs. suppression)
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