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Target intelligence / Profile preview
Matrix 2 ion channel protein (M2)
- Target
- M2
- Molecular classification
- Ion channel, Viroporin, Integral membrane protein
01
Overview
The Matrix 2 (M2) ion channel protein is an integral membrane protein found in influenza A virus and is essential for the virus's life cycle. It functions as a proton-selective ion channel, playing critical roles during viral entry, uncoating, assembly, and release. The functional channel is formed by four M2 monomers assembling together. The antiviral drug amantadine specifically inhibits influenza A virus M2 ion channel activity; resistance to amantadine arises from mutations within the TM domain.
- Other names
- M2 proteinM2 ion channel
02
Mechanism of action
Inhibition of M2 proton channel activity, blocking proton influx into the virion and preventing uncoating
03
Biological functions
Proton transportViral uncoatingpH regulationVirus assemblyVirus release
04
Disease associations
Infection
05
Safety considerations
Drug resistance (mutations in the TM domain)Limited efficacy due to resistance
06
Interacting drugs
Amantadine
1 more in the full profile.
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