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Target intelligence / Profile preview
Matrix-M Adjuvant (Matrix-M)
- Target
- Matrix-M
- Molecular classification
- Adjuvant, Saponin, Nanoparticle
01
Overview
Matrix-M is a proprietary saponin-based vaccine adjuvant developed by Novavax. It is designed to enhance the immune response to co-administered antigens, thereby improving vaccine efficacy. The adjuvant consists of nanoparticles formed from purified saponins derived from the bark of the Quillaja saponaria Molina tree, combined with cholesterol and phospholipids. It is composed of Matrix-A and Matrix-C fractions, balancing potency and safety.
- Other names
- Novavax Matrix-MSaponin-based adjuvantQuillaja saponaria adjuvantMatrix-A/C adjuvant
02
Mechanism of action
Activates innate immunity locally/regionally; enhances B/T-cell responses to co-administered antigens.
03
Biological functions
Immune system stimulationEnhancement of antibody responseActivation of innate immune cellsPromotion of T cell responseDose-sparing
04
Disease associations
Infection (vaccine adjuvant)
05
Safety considerations
Reactogenicity (lower than earlier saponin formulations)Injection site reactions
06
Interacting drugs
NVX-CoV2373 (COVID-19 vaccine)
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