Matrix metallopeptidase 12 pseudogene

The matrix metallopeptidase 12 pseudogene is a *non-functional genomic sequence* related to the matrix metallopeptidase 12 (MMP12) gene. Unlike the functional MMP12 gene, which encodes macrophage metalloelastase—a zinc-dependent endopeptidase involved in extracellular matrix degradation[1][3][5]—this pseudogene does not produce a viable protein. Pseudogenes are typically considered "dead" gene copies that have lost their protein-coding capability due to mutations, deletions, or insertions, and therefore do not have a direct protein function or role as drug targets. While functional matrix metallopeptidase 12 (MMP12) is an enzyme with roles in tissue remodeling, inflammation, and disease[1][3][5], *pseudogenes* like LOC100129404 (ENSG00000249213) do not encode proteins and are not classified as receptors, enzymes, or therapeutic targets[3]. Pseudogenes can sometimes play regulatory or evolutionary roles at the RNA level, but this is not synonymous with being a conventional drug target or receptor. If you are looking for information on the functional protein, refer to the canonical MMP12 ("Matrix metallopeptidase 12", also known as Macrophage metalloelastase)[1][3]. For this pseudogene, no further structured target information applies.

Other names

LOC100129404ENSG00000249213