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Target intelligence / Profile preview
Matrix metallopeptidase 9 (MMP9)
- Target
- MMP9
- Molecular classification
- Matrix metalloproteinases, Zinc-dependent endopeptidases, Enzyme
01
Overview
Matrix metallopeptidase 9 (MMP9) is a zinc-dependent endopeptidase belonging to the matrix metalloproteinase family. It plays a crucial role in the degradation of extracellular matrix components, influencing processes such as tissue remodeling, inflammation, angiogenesis, and tumor metastasis. MMP9 is synthesized as an inactive zymogen and activated by proteolytic cleavage. Elevated MMP9 levels are associated with various diseases, making it a potential therapeutic target and biomarker.
- Other names
- Gelatinase B92 kDa type IV collagenase92 kDa gelatinase
02
Mechanism of action
Inhibition of MMP9 enzymatic activity
03
Biological functions
ECM degradation/remodelingCytokine activation/releaseAngiogenesisLeukocyte migrationWound healingTissue remodeling
04
Disease associations
CancerCardiovascular diseaseRheumatoid arthritisCOPDMultiple sclerosisAsthmaInflammationFibrosis
05
Safety considerations
Potential for off-target effects due to broad substrate specificityImpaired wound healingMusculoskeletal side effects
06
Biomarkers
Tumor invasion/metastasis (cancer)Vascular remodeling/fibrosis (cardiovascular disease)
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