Target intelligence / Profile preview

Matrix Metalloproteinase (MMP)

Target: MMP
Molecular classification: Enzyme, Protease, Metzincin superfamily

Overview

Matrix metalloproteinases (MMPs) are a family of zinc-dependent, calcium-containing endopeptidases that play a central role in the remodeling and degradation of the extracellular matrix (ECM). They are involved in various physiological processes and implicated in pathological conditions including cancer, cardiovascular diseases, arthritis, and neurodegeneration. MMP activity is tightly regulated, and imbalance between MMPs and their inhibitors (TIMPs) can contribute to disease progression.

Other names: Matrix MetallopeptidaseMatrixin

Mechanism of action

Inhibition of MMP activity

Biological functions

Extracellular matrix remodelingProtein degradationCell proliferation regulationCell migration regulationCell adhesion regulationAngiogenesis regulationApoptosis regulationHost defenseTissue repair

Disease associations

Cancer metastasisCancer invasionCardiovascular diseaseHeart failureArthritisFibrosisNeurodegeneration

Safety considerations

Imbalance between MMPs and TIMPs leading to excessive ECM degradationPotential for off-target effects due to broad substrate specificity

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