Matrix metalloproteinase 12 (MMP-12)

Matrix metalloproteinase 12 (MMP-12), also known as macrophage metalloelastase, is a zinc-dependent endopeptidase in the matrix metalloproteinase family, primarily secreted by macrophages[1][2]. MMP-12 plays a crucial role in the degradation of extracellular matrix proteins, especially elastin, during physiological processes such as tissue remodeling, embryonic development, and reproduction, and in pathological conditions including atherosclerosis, aneurysm, emphysema, arthritis, and tumor metastasis[1][2][3]. High MMP-12 expression is associated with advanced atherosclerotic plaques, plaque vulnerability, and the promotion of apoptosis in plaque macrophages, contributing to disease progression and instability[3]. It is a validated therapeutic target for several diseases with tissue remodeling and inflammatory components, but clinical targeting is limited by broad MMP inhibitor toxicity[2][3].

Other names

macrophage metalloelastasemacrophage elastaseMMEME

Inhibition of proteolytic (elastolytic) activity to prevent extracellular matrix degradation and tissue remodeling