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Target intelligence / Profile preview
Matrix metalloproteinase-13 (MMP-13)
- Target
- MMP-13
- Molecular classification
- Enzyme, Matrix metalloproteinase, Zinc-dependent endopeptidase
01
Overview
Matrix metalloproteinase-13 (MMP-13), also known as collagenase 3, is a zinc-dependent endopeptidase that degrades components of the extracellular matrix (ECM), particularly type II collagen. It plays a key role in cartilage and bone remodeling, and its overexpression is implicated in osteoarthritis, rheumatoid arthritis, and cancer invasion/metastasis, making it an attractive drug target.
- Other names
- CLG3MANDP1Matrix metallopeptidase 13MDSTCollagenase 3
02
Mechanism of action
Inhibition of MMP-13 enzymatic activity, preventing ECM degradation
03
Biological functions
Cartilage remodelingBone remodelingECM turnoverEmbryonic development (skeletal)Tissue remodelingBone mineralization
04
Disease associations
OsteoarthritisRheumatoid arthritisCancer invasionMetastasis
05
Safety considerations
Potential for off-target effects due to similarity to other MMPsInhibition of essential physiological functions mediated by other MMPs
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