Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Matrix metalloproteinase 14 (MMP14)
- Target
- MMP14
- Molecular classification
- Membrane-type matrix metalloproteinase, Enzyme
01
Overview
Matrix metalloproteinase 14 (MMP14), also known as MT1-MMP, is a membrane-bound enzyme that plays a central role in extracellular matrix (ECM) remodeling and cellular migration. It cleaves various ECM components and activates pro-MMP2, facilitating ECM degradation. MMP14 is involved in normal physiological processes such as embryonic development and tissue remodeling, but also plays roles in pathological conditions such as arthritis and cancer metastasis.
- Other names
- MT1-MMP
02
Mechanism of action
Inhibition of MMP14 enzymatic activity, disruption of interactions with other cell surface molecules, or blocking its expression.
03
Biological functions
Pericellular proteolysisExtracellular matrix remodelingCellular migrationTendon/collagen fiber maturationTumor invasion/metastasisAngiogenesis regulation
04
Disease associations
Cancer metastasisArthritis progressionSkeletal/connective tissue disordersAgingSenescence
05
Safety considerations
Potential for off-target effects due to broad substrate specificity.Disruption of normal ECM remodeling processes.Premature aging phenotypes and shortened lifespan (based on knockout mouse models).
Beyond the preview
Go deeper on Matrix metalloproteinase 14 (MMP14).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Matrix metalloproteinase 14 (MMP14).