Matrix metalloproteinase-14 messenger RNA (MMP14 mRNA) (MMP14 mRNA)

Matrix metalloproteinase-14 (MMP14) messenger RNA is the transcript encoding the MT1-MMP protein, a membrane-bound endopeptidase essential for degrading extracellular matrix (ECM) components like collagen and fibronectin (UniProt P50281). It plays a critical role in physiological processes such as tissue remodeling, wound healing, and embryonic development, and serves as a primary activator of pro-MMP2 (PubMed 8015608). In various malignancies, including breast, lung, and gastric cancers, MMP14 mRNA is significantly overexpressed, which facilitates tumor cell invasion, metastasis, and angiogenesis (NIH 1.1.4, PubMed 22065321). High levels of MMP14 mRNA are often associated with poor clinical prognosis and shorter overall survival in patients (NIH 1.1.1, European Review 1.2.2). Therapeutic strategies targeting the mRNA, such as siRNA and antisense oligonucleotides, are being explored to selectively silence MMP14 expression and overcome the selectivity issues of broad-spectrum protease inhibitors (PubMed 1.4.1, Frontiers 1.2.3). These RNA-based approaches aim to inhibit the invasive phenotype of cancer cells by preventing the synthesis of the MMP14 protein at the pre-translational level (MDPI 1.1.5).

Other names

MT1-MMP mRNAMembrane-type 1 matrix metalloproteinase mRNAMMP-14 mRNAMatrix metallopeptidase 14 mRNA

RNA interference (RNAi) and antisense-mediated mRNA degradation or translation inhibition.