Target intelligence / Profile preview

Matrix Metalloproteinase-3 (MMP-3)

Target: MMP-3
Molecular classification: Matrix Metalloproteinase, Enzyme

Overview

Matrix metalloproteinase-3 (MMP-3), also known as stromelysin-1, is a zinc-dependent endopeptidase involved in the degradation and remodeling of the extracellular matrix. It has a broad substrate specificity, degrading collagens, fibronectin, laminins, and proteoglycans. MMP-3 also activates other pro-MMPs. It plays roles in normal tissue remodeling, wound healing, and various diseases including osteoarthritis, atherosclerosis, cancer, and neurodegenerative conditions. Its activity is regulated by TIMPs.

Other names: Stromelysin-1

Mechanism of action

Inhibition of MMP-3 enzymatic activity.

Biological functions

Extracellular matrix degradationTissue remodelingActivation of other MMPs

Disease associations

OsteoarthritisAtherosclerosisCancer metastasisNeurodegenerative disease

Safety considerations

Potential for off-target effects due to broad substrate specificity.Disruption of normal tissue remodeling processes.

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