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Matrix Metalloproteinase 7 (MMP7)
- Target
- MMP7
- Molecular classification
- Matrix Metalloproteinase, Enzyme
01
Overview
Matrix metalloproteinase 7 (MMP7), also known as matrilysin, is a zinc-dependent endopeptidase involved in the breakdown of extracellular matrix (ECM) components. It plays a role in tissue remodeling, embryonic development, and wound healing, as well as in pathological conditions like cancer metastasis and fibrosis. MMP7 degrades various ECM proteins and can activate other pro-MMPs. Overexpression is associated with tumor malignancy, cardiovascular disease, and other conditions.
- Other names
- MatrilysinMMP-7
02
Mechanism of action
Inhibition of MMP7 activity to prevent ECM degradation and downstream effects.
03
Biological functions
ECM protein degradationActivation of other pro-MMPsTissue remodeling
04
Disease associations
Cancer progression/metastasisCardiovascular diseasePulmonary arterial hypertensionLiver fibrosisDiabetes mellitus
05
Safety considerations
Potential for off-target effects on other MMPsDisruption of normal tissue remodeling processes
06
Biomarkers
Elevated serum MMP7 levels in cancerElevated serum MMP7 levels in cardiovascular diseaseElevated serum MMP7 levels in pulmonary arterial hypertension
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