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Target intelligence / Profile preview
Matrix Protein M1 (M1)
- Target
- M1
- Molecular classification
- Structural protein, Matrix protein, Viral protein
01
Overview
Matrix protein M1 is a multifunctional, highly conserved structural protein of the influenza A virus. It is the most abundant protein in influenza virions and plays essential roles in viral assembly, morphology, stability, and the regulation of various steps in the viral life cycle. It is a promising antiviral target due to its central role in the viral life cycle and its relatively conserved sequence compared to other influenza proteins like HA and NA.
- Other names
- Influenza A virus matrix protein M1M1 protein
02
Mechanism of action
Inhibition of M1 oligomerization; disruption of M1-RNA interaction; interference with M1-mediated viral assembly and budding
03
Biological functions
Structural supportViral assemblyViral buddingRNA bindingRegulation of viral transcriptionRegulation of viral RNA exportVirion stability
04
Disease associations
InfectionInfluenza
05
Safety considerations
Potential for off-target effects due to interaction with host cell proteinsDevelopment of drug resistance
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