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Target intelligence / Profile preview
Matrix remodeling-associated protein 8 (MXRA8)
- Target
- MXRA8
- Molecular classification
- Type I transmembrane protein, Receptor
01
Overview
Matrix remodeling-associated protein 8 (MXRA8) is a type I transmembrane protein involved in cartilage formation, angiogenesis regulation, and blood-brain barrier maintenance. It also acts as an entry receptor for arthritogenic alphaviruses. In cancer, high MXRA8 expression is associated with poor prognosis in glioma and identifies a subset of cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma. Targeting MXRA8 has shown promise in inhibiting tumor cell proliferation and inducing ferroptosis.
02
Mechanism of action
Inhibition of MXRA8 leads to increased NCOA4 expression and decreased FTH1 levels, promoting ferroptosis. Antibody-based therapies targeting MXRA8.
03
Biological functions
Angiogenesis regulationCartilage formationBlood-brain barrier maintenanceViral entry
04
Disease associations
CancerViral infections
05
Safety considerations
Potential impact on normal physiological processes such as cartilage formation and angiogenesis regulation if targeted systemically.
06
Interacting drugs
Temozolomide (TMZ)
07
Biomarkers
MXRA8 expression level in gliomaMXRA8 as a marker for cancer-associated fibroblasts (CAFs) in pancreatic ductal adenocarcinoma
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