Matrix remodeling targets

Matrix remodeling targets represent a broad class of enzymes and proteins responsible for the dynamic modification of the extracellular matrix (ECM) architecture. Key members include matrix metalloproteinases (MMPs), which degrade ECM components, and lysyl oxidases (LOX), which catalyze the cross-linking of collagen and elastin fibers (Source: PubMed, PMID: 30635914). These targets are fundamental to physiological tissue homeostasis, facilitating cell migration, proliferation, and wound repair. In pathological states, dysregulated matrix remodeling contributes to the "stiffening" of the tumor microenvironment in cancer and the excessive deposition of fibrous tissue in organ fibrosis (Source: Nature Reviews Drug Discovery, 2020). Pharmacological strategies have historically focused on broad-spectrum inhibitors, but modern approaches aim for high specificity to avoid the systemic toxicities, such as musculoskeletal syndrome, that plagued early clinical candidates (Source: Science Translational Medicine, 2016).

Other names

Extracellular matrix remodeling enzymesECM remodeling proteinsMatrix-modifying enzymesMatrix-modifying proteins

Inhibition of proteolytic enzymes or cross-linking proteins to prevent pathological degradation or stiffening of the extracellular matrix.