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Maxi-K Channel Alpha Subunit (BK Channel Alpha Subunit)
- Target
- BK Channel Alpha Subunit
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel, Calcium-activated potassium channel
01
Overview
The BK (Big Potassium) channel alpha subunit, encoded by the KCNMA1 gene, forms a homotetrameric, large-conductance, voltage and calcium-activated potassium channel. It regulates smooth muscle tone, neuronal excitability, and neurotransmitter release by conducting potassium ions out of the cell upon activation by membrane depolarization and intracellular calcium increase. Dysfunction is implicated in hypertension and neurological disorders, making it a therapeutic target.
- Other names
- BK channel alpha subunitLarge conductance calcium-activated potassium channel, subfamily M, alpha member 1 (KCa1.1)Slo1MaxiK channelKCa1.1
02
Mechanism of action
Modulation of potassium ion flow, leading to membrane hyperpolarization and reduced cell excitability.
03
Biological functions
Regulation of smooth muscle toneModulation of neuronal excitabilityShaping action potentialsControl of neurotransmitter releaseMembrane repolarizationMembrane hyperpolarization
04
Disease associations
HypertensionNeurological disordersCardiovascular diseases
05
Safety considerations
Potential for altering neuronal excitabilityPotential for altering vascular tone
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