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MCTP1 antisense RNA 1 (MCTP1-AS1)
- Target
- MCTP1-AS1
- Molecular classification
- Long noncoding RNA (lncRNA), Antisense RNA, Other
01
Overview
MCTP1 antisense RNA 1 (MCTP1-AS1) is a long noncoding RNA transcribed antisense to the protein-coding gene MCTP1. It is downregulated in endometrial cancer tissues and cell lines. Overexpression of MCTP1-AS1 inhibits cell proliferation, migration, invasion, and the EMT process in endometrial cancer cells, and exerts this effect by targeting the miR-650/SMAD7 axis, which regulates the TGF-β/SMAD signaling pathway and affects cancer metastasis and progression[8][7]. As a member of the antisense lncRNA class, it functions by regulating gene expression, predominantly at the post-transcriptional level, and may serve as a biomarker in cancer diagnostics and research but is not currently targeted by approved drugs[7][8].
- Other names
- MCTP1 antisense RNA 1MCTP1-AS1ENST00000503710NR_189169.1
02
Biological functions
Regulation of gene expressionInhibition of cell proliferationInhibition of cell migration and invasionSuppression of EMT (epithelial-to-mesenchymal transition)Modulation of miRNA activity (specifically miR-650)
03
Disease associations
Cancer (Notably endometrial cancer)Other
04
Biomarkers
MCTP1-AS1 expression as a marker for endometrial cancer progressionDownregulation in cancerous tissue as a potential prognostic or diagnostic marker
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