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Target intelligence / Profile preview
Mdm2 Proto-Oncogene Protein (MDM2)
- Target
- MDM2
- Molecular classification
- E3 ubiquitin ligase, Proto-oncogene
01
Overview
MDM2 is a proto-oncogene encoding a nuclear-localized E3 ubiquitin ligase that primarily regulates the tumor suppressor p53. It binds to p53, inhibiting its transcriptional activity and promoting its degradation, forming an autoregulatory negative feedback loop. MDM2 also targets other proteins for ubiquitination. Overexpression or amplification of MDM2 is observed in various cancers, leading to inactivation of p53-mediated apoptotic and cell cycle arrest functions.
- Other names
- ACTFShdm2HDMXLSKBOncoprotein Mdm2P53-Binding Protein
02
Mechanism of action
Inhibition of p53 transcriptional activity and promotion of its degradation
03
Biological functions
Regulation of cell cycle progressionRegulation of apoptosisRegulation of p53 activityProtein ubiquitinationTranscriptional regulation
04
Disease associations
CancerLessel-Kubisch SyndromeAccelerated Tumor FormationDedifferentiated Liposarcoma
05
Safety considerations
Potential for off-target effects due to broad substrate specificity of MDM2
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