Measles morbillivirus antigens (MeV antigens) (MeV antigens)

Measles morbillivirus antigens encompass the structural and functional proteins of the measles virus, a highly contagious member of the Paramyxoviridae family (Source: StatPearls, Measles). The primary targets for the immune system and therapeutic intervention are the surface glycoproteins: the Hemagglutinin (H) protein, responsible for receptor binding to SLAMF1 (CD150) and Nectin-4, and the Fusion (F) protein, which mediates membrane fusion (Source: UniProt, P08362, P03372). Other key antigens include the Nucleoprotein (N), Phosphoprotein (P), and Large (L) protein, which form the viral replication complex, as well as the Matrix (M) protein (Source: Wikipedia, Measles virus). These antigens are the basis for the highly effective live-attenuated measles vaccines, such as the MMR vaccine, which elicit neutralizing antibodies and T-cell responses (Source: CDC, Measles Vaccination). In the context of disease, these proteins facilitate viral entry and contribute to the profound immunosuppression and systemic infection characteristic of measles (Source: WHO, Measles). Experimental drugs like ERDRP-0519 are being developed to target the viral polymerase (L protein) to inhibit replication (Source: Journal of Virology, 2016).

Other names

Measles virus antigensMeV proteinsRubeola virus antigensMeasles virus structural proteinsMeasles virus surface glycoproteins

Vaccines induce neutralizing antibodies against H and F proteins to prevent viral entry; antivirals like Ribavirin and ERDRP-0519 inhibit viral RNA polymerase activity; Vitamin A supports immune function and mucosal integrity (Source: CDC, WHO, Journal of Virology).