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Target intelligence / Profile preview
Measles Virus Hemagglutinin Glycoprotein
- Molecular classification
- Viral envelope protein, Glycoprotein, Attachment protein
01
Overview
The measles virus H glycoprotein is an essential envelope protein responsible for attachment to host cells. It binds to cellular receptors such as SLAM/CD150, CD46, and Nectin-4, initiating the process of viral entry. The H protein is a major target for neutralizing antibodies and is highly conserved, making it a crucial component in the efficacy of measles vaccines. Mutations in the receptor binding site are strongly selected against due to impairing infectivity. Structural studies have revealed important details about its receptor-binding mechanism.
- Other names
- H glycoproteinMV-HMeasles virus H protein
02
Mechanism of action
Binds to cellular receptors (SLAM/CD150, CD46, Nectin-4) to initiate viral entry.
03
Biological functions
Viral attachmentReceptor bindingMembrane fusion initiationImmune evasion
04
Disease associations
InfectionMeasles pathogenesis
05
Safety considerations
Targeting highly conserved regions to avoid resistance development.Potential for off-target effects if inhibitors are not highly specific.
06
Interacting drugs
Neutralizing antibodies
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