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Target intelligence / Profile preview
Measles Virus Hemagglutinin Protein (MV-H)
- Target
- MV-H
- Molecular classification
- Viral attachment protein, Type I integral membrane glycoprotein
01
Overview
The measles virus hemagglutinin protein (MV-H) is a type I integral membrane glycoprotein on the measles virus surface. It mediates viral attachment to host cells by binding to receptors like SLAM/CD150, Nectin-4/PVRL4, and CD46. Receptor binding triggers conformational changes in MV-H, activating the fusion (F) protein to initiate membrane fusion and viral entry. MV-H is a major target for neutralizing antibodies and plays a critical role in determining tissue tropism and host range.
- Other names
- H proteinMeV H proteinMeasles virus H proteinHemagglutinin
02
Mechanism of action
Currently, no drugs directly target MV-H. Therapeutic strategies focus on preventing infection via vaccination which elicits neutralizing antibodies against MV-H.
03
Biological functions
Receptor bindingMembrane fusionViral entryImmune evasion
04
Disease associations
MeaslesViral infection
05
Safety considerations
Antigenic variationGlycosylation maskingPotential for escape mutants
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