Mechanical gastric volume reduction

Mechanical gastric volume reduction is not a molecular or cellular therapeutic target such as a receptor, enzyme, or transporter. Instead, it refers to a class of medical interventions and devices designed to physically reduce the functional capacity of the stomach in order to induce weight loss in patients with obesity. These interventions include surgical procedures like sleeve gastrectomy and endoscopic approaches such as intragastric balloons and tissue apposition devices. The primary mechanism is mechanical restriction—reducing stomach size limits food intake and promotes early satiety—but additional effects may include delayed gastric emptying and changes in gut hormone signaling (e.g., ghrelin suppression after surgery). Devices used for mechanical gastric volume reduction are not themselves biological targets but act by altering gastrointestinal anatomy or function. Therefore, "Mechanical gastric volume reduction" should not be considered a canonical drug target; rather it describes an interventional strategy or procedural approach.

Other names

Gastric volume reductionMechanical gastric restrictionGastric restrictive procedureBariatric device (mechanical)Endoscopic gastric volume reduction